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Methadone is most commonly used as part of medication-assisted treatment (MAT) programs for opioid dependence, particularly for individuals addicted to heroin or prescription opioids. Methadone maintenance therapy (MMT) involves the long-term administration of methadone to reduce cravings and withdrawal symptoms, stabilize opioid-dependent individuals, and support recovery. Methadone is also used for the management of chronic pain that is not adequately controlled by other opioid medications or non-opioid pain relievers. It can be prescribed for conditions such as cancer-related pain, neuropathic pain, and severe musculoskeletal pain. Methadone's long duration of action and unique pharmacological profile make it an option for certain patients who require around-the-clock pain relief.

 

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